Bio-Slender is an an oral therapy for the treatment of over weight and obesity. The pharmacology of its principal ingredients are.

Green tea Camellia sinensis

Action: Green Tea catechins have antioxidant activity.

Pharmacokinetics: The pharmacokinetics of green tea catechins in humans remain incompletly understood. The are absorbed from the gastrointestinal tract following ingestion, and blood levels of various catechins have been measured. However, the extent of thier absorbtion, as well as their distribution, metabolism and excretion is unclear. A recent study indicates that green tea catechins are mainly found in the protien rich fraction of plasma and high density lipoproteins (LDL).

Dandelion root Taraxacum officinale

Stimulates digestive functions and is considered an excellent cleansing tonic for the liver Dandelion root is regarded as a "liver tonic", which has led to its use for many illnesses traditionally believed to be caused by a "sluggish" or "congested" liver, including constipation, headaches, eye problems, gout, skin problems, fatigue and boils.

Dandelion root contains sesquiterpene lactones (eudesmanolides and germacranolides); triterpenes (b-amyrin, taraxol, and taraxerol); carbohydrates (inulin 2% in spring and up to 40% in autumn); carotenoids (lutein); fatty acids (myristic); flavonoids (apigenin and luteolin); minerals (potassium 1.84.5%); phenolic acids (caffeic acid and chlorogenic acid); phytosterols (sitosterol, stigmasterol, and taraxasterol); sugars (fructose approx. 18% in spring); vitamins (vitamin A up to 14,000 iu/100g); choline; mucilage (approx. 1.1%); and pectin

Garcinia Cambogia

Garcinia Cambogia Extract, also known as Citrimax, contains 50% hydroxycitric acid (HCA) which works with the body's own natural use of calories. It suppresses appetite by redirecting calories away from fat production and towards the formation of glycogen. Glycogen is the stored form of glucose, one of the body's primary sources of energy. Increased glycogen production and storage is the body's normal way of signaling the brain's satiety center that enough food has been eaten. HCA is not a central nervous system stimulant. HCA is most effective at influencing appetite, increasing energy levels and inhibiting fat and cholesterol production.

Hydroxycitric acid is a competitive inhibitor of the enzyme adenosine triphoshate-citrate (pro-3S) - lyase or ATP citrate lyase. In the cytosol, ATP citrate lyase catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetly CoA). Acetyl CoA is used in the synthesis of fatty acids, cholesterol, triglycerides and in the synthesis of acetylchorine in the central nervous system.

Oxaloactate may enter the gluconeogenic pathway, which can lead to the production of glucose and glycogen. It is believed that the putative anti obesity effect of hydroxycitric acid is due to suppression of fatty acid and fat synthesis. In addition hydroxycitric acid is though to suppress food intake via an anorectic effect. This is believed to be accounted for by hydroxycitric acid´s stimulation of liver gluconeogenesis.

5-HTP -Griffonia simplicifolia Extract

-Griffonia simplicifolia Extract (5-HTP) is a precursor to Serotonin, the neurotransmitter that regulates mood, behavior, appetite, and sleep function. 5-HTP is produced naturally in the body when the amino acid L-tryptophan combines with vitamin C. In clinical trials, researchers have observed that approximately seventy percent of orally administered 5-HTP is absorbed directly into the blood stream. Unlike other dietary supplements, 5-HTP molecules are believed to be small enough to pass directly through the blood-brain barrier, thus increasing the availability of Serotonin in the Central Nervous System (CNS). Further analysis shows that 5-HTP administration also stimulates the activity of the neurochemicals Norepinephrine, Dopamine and Melatonin. It is thought that together, these mechanisms of action promote a healthy neurotransmitter balance in the brain and provide positive support for a depressed mood and mild to moderate mood swings caused by everyday stress, occasional nervousness, nervous tension and anxiety.

5-HTP has putative bariatric actions. Serotonin is known to regulate feeding behavior and decrease food intake in humans and rodents. A recent study suggests that this effect may be mediated via leptin. Serum leptin levels in mice were found to increase following systemic injections of 5-HTP. Leptin, an adipocytederived protein product of the ob (obesity) gene, is a multifunctional polypeptide associated with the development of obesity-related disorders in humans.

Pharmacokinetics

A significant amount of an ingested dose of 5-HTP is decarboxylated in the small intestine to 5-hydroxytryptamine (5-HT or Serotonin) The efficiency of absorption of 5-HTP, as well as its decarboxylation product serotonin, is approximately 47% to 84%. Absorption occurs by an active transport process. 5-HTP is transported by the portal circulation to the liver where approximately 25% of the administered dose is metabolized via B6-dependent L-aromatic amino acid decarboxylase to 5-HT. 5-HT is subsequently metabolized to 5-hydroxyindoleacetic acid (5-HIAA)

5-HTP that is not metabolized in the liver is transported by the general circulation to the various tissues in the body, including the the brain. 5-HTP readily cross the blood-brain barrier, and is converted to serotonin in brain cells. 5-HIAA is the principal renal excretion product of 5-HTP.